Oxosorbicillinol

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August undefined, 2024

WebMay 28, 2002 · ChemInform Abstract Biosynthetic incorporation of labeled sodium acetate into oxosorbicillinol (I) shows that it is derived from six acetate units. Subsequent bioconversion of the labeled oxosorbicillinol (I) to bisvertinolone suggests that bisvertinolone is biosynthesized from (I) and sorbicillinol in a Michael‐type reaction. Journal WebJan 13, 2024 · In contrast to prior reports, SorD catalyses neither the oxidation of 2′,3′‐dihydrosorbicillin to sorbicillin nor the oxidation of sorbicillinol to oxosorbicillinol. This is the first report that both the intermolecular Diels–Alder and Michael dimerization reactions, as well as the epoxidation of sorbicillinol are catalysed in vivo by SorD.

Diels–Alder Reactions During the Biosynthesis of Sorbicillinoids

WebJun 15, 2024 · Other sorbicillinoids, such as oxosorbicillinol and dihydrosorbicillinol, were shown to exhibit antimicrobial activity against Staphylococcus aureus and Bacillus … WebBiosynthetic incorporation of labeled sodium acetate into oxosorbicillinol in Trichoderma sp. USF-2690 suggests that oxosorbicillinol is derived from six acetate units, and … memory foam king size mattress amazon

Oxacillin - Wikipedia

WebAug 23, 2024 · Language links are at the top of the page across from the title. WebAbe N, Yamamoto K, Hirota A: Novel fungal metabolites, demethylsorbicillin and oxosorbicillinol, isolated from Trichoderma sp. USF-2690. Biosci Biotechnol Biochem. 2000 Mar;64(3):620-2. doi: 10.1271/bbb.64.620. [PubMed:10803967 ] Maskey RP, Grun-Wollny I, Laatsch H: Sorbicillin analogues and related dimeric compounds from … WebJan 1, 2000 · Abstract. The novel compounds, demethylsorbicillin (1) and oxosorbicillinol (2), were isolated from a fermentation broth of Trichoderma sp. USF-2690. The structures of these compounds, which were determined from spectroscopic evidence, suggest the possibility that methylation at C-6 and oxidation at C-1 and C-6 of sorbicillin were … memory foam king mattress set

Mechanism and regulation of sorbicillin biosynthesis by …

Frontiers In Vivo Study of the Sorbicillinoid Gene Cluster in ...

WebMay 22, 2014 · A new lipoxygenase inhibitor, 6'-hydroxyoxosorbicillinol (1, C 14 H 16 O 6), was identified from a culture of Penicillium sp.A known compound, oxosorbicillinol (2, C 14 H 16 O 5), was also isolated.Compound 1 showed an approximately 10 times greater inhibitory effect on soybean lipoxygenase (IC 50, 16 µ M) than 2 (IC 50, 150 µ M), and … memory foam king mattress dealsWebFeb 1, 2009 · Biosynthetic incorporation of labeled sodium acetate into oxosorbicillinol in Trichoderma sp. USF-2690 suggests that oxosorbicillinol is derived from six acetate units, and subsequent bioconversion … Expand. 20. Save. Alert. Studies towards Trichodimerol: Novel Cascade Reactions and Polycyclic Frameworks. memory foam king size pillow

"WebThe proposed biosynthetic route is rather unusual, featuring the formation of an unprecedented uncyclised tetracarbonyl 6 by a fungal polyketide synthase (PKS), 6 which is then hydroxylated to give 7 prior to cyclisation to form oxosorbicillinol 8. This is then reduced to the alcohol 9 which has not been observed. " - Oxosorbicillinol

Oxosorbicillinol

WebMay 23, 2024 · A stable tautomer of oxosorbicillinol (7) was characterized as 6, and the recently described 7-deacetoxyyanuthone (8) was reisolated. The additionally isolated rezishanones A-D (12-13c) are the ... WebJan 1, 2000 · Abstract. The novel compounds, demethylsorbicillin (1) and oxosorbicillinol (2), were isolated from a fermentation broth of Trichoderma sp. USF-2690. The …

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WebOct 20, 2024 · This hypothetical compound has the same empiric formula as oxosorbicillinol and epoxysorbicillinol, and might be compound F_265 (Table 2) that was detected in all sorbicillinoid producing strains (Figure 5). Its higher levels in Δsor4 could be explained by a feedback of the accumulating dihydrosorbicillinol on Sor1. WebOxosorbicillinol C14H16O5 CID 10015650 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...

WebSep 21, 2024 · The flavin-dependent monooxygenase SorD from Penicillium chrysogenum (PcSorD) utilizes sorbicillinol to catalyze a broad scope of reactions: formation of … WebJun 1, 2016 · Molecules 2016, 21, 715 3 of 19 Table 1. Occurrence of the monomeric sorbicillinoids (1–30) in fungi.Sorbicillinoid Fungus and its Origin Ref. Sorbicillinol (1) Trichoderma sp. USF-2690 from a soil sample [14]Epoxysorbicillinol (2) Trichoderma longibrachiatum from the sponge Haliclona sp. [20]Oxosorbicillinol (3)Penicillium …

WebMar 1, 2002 · Biosynthetic incorporation of labeled sodium acetate into oxosorbicillinol in Trichoderma sp. USF-2690 suggests that oxosorbicillinol is derived from six acetate … WebFeb 10, 2001 · Chemo-enzymatic Total Synthesis of Oxosorbicillinol, Sorrentanone, Rezishanones B and C, Sorbicatechol A, Bisvertinolone, and (+)-Epoxysorbicillinol. Angewandte Chemie International Edition 2024 , 57 (44) , 14650-14653.

WebSorbicillinoids are a class of fungal metabolites with a cyclic hexaketide nucleus, which contains a typical or modified sorbyl sidechain [1,2].Since the isolation of the first member of the sorbicillinoid family 60 years ago (sorbicillin, from the fungus Penicillium notatum) [], approximately 100 sorbicillin derivatives have been reported from several strains of fungi …

WebOct 1, 2024 · oxosorbicillinol was a key intermediate for sorbicillinol synthesis via a hypothetical compound, and that sorbicillin was derived from sorbicillinol ( Abe et al., 2002 ). memory foam king size bedWebOct 20, 2024 · This hypothetical compound has the same empiric formula as oxosorbicillinol and epoxysorbicillinol, and might be compound F_265 (Table 2) that … memory foam king size mattress topperWebMay 23, 2024 · By using recombinant oxidoreductase SorbC and readily accessible sorbicillin‐type synthetic precursors, we have developed enantioselective, one‐pot chemo‐enzymatic routes to a broad range of sorbicillinoids, thereby establishing total syntheses of oxosorbicillinol, sorrentanone, rezishanones B and C, sorbicatechol A, … memory foam king size mattress ukWebMay 28, 2010 · Moreover, Abe [11] proved OH-4a was cis to CH 3 -1a, based on the elucidation of the biosynthesis of bisvertinolone from oxosorbicillinol and sorbicillinol. But judging from molecular models we ... memory foam king size mattress setWebJan 13, 2024 · In contrast to prior reports, SorD catalyses neither the oxidation of 2′,3′-dihydrosorbicillin to sorbicillin nor the oxidation of sorbicillinol to oxosorbicillinol. This is … memory foam kissen testWebMay 23, 2024 · Sorbicillinoids made easy: The first stereoselective total syntheses of the structurally diverse sorbicillinoids oxosorbicillinol, sorrentanone, rezishanones B and C, … memory foam king size mattress priceWebwith that of oxosorbicillinol. The polarity of the optical rotation values for 1 and 2, both of which were negative, suggests that the stereochemistry of C-6 in 1 is the same as that in 2,anR conﬁguration. Abe et al.6–9) have reported the isolation of sorbicillin compounds, includ-ing oxosorbicillinol (2), from the fungus Trichoderma sp. memory foam king size pillows