Plectin protein
WebbThe Pathology section contains mRNA and protein expression data from 17 different forms of human cancer. Correlation analysis based on mRNA expression levels of human … Webb30 apr. 1996 · Plectin, a 500-kDa intermediate filament binding protein, has been proposed to provide mechanical strength to cells and tissues by acting as a cross-linking element …
Plectin protein
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WebbPlectin is a highly preserved structural protein of the cytoskeleton expressed in several cell types, including skeletal muscle, postsynaptic membrane, and skin. Plectin deficiency … Webb8 jan. 2024 · The PLEC gene (PLEC is the acronym for plectin) is a protein-coding gene located on 8q24.3. Until 2010, this gene locus was named Plectin 1 (symbol PLEC1 in humans), and the gene product was referred to as "hemidesmosomal protein 1" or "Plectin 1, intermediate filament binding 500kDa". These designations have been replaced by …
Webb27 feb. 2024 · Plectin has been shown to bind directly to several IF proteins, including epithelial keratins (both types I and II), neurofilaments, vimentin, desmin, glial fibrillary … Webb15 sep. 2013 · Plectin phosphorylated at S4642 was reduced at sites of IF network anchorage along cell-substrate contacts in both skin and cultured keratinocytes. Treatment of SK-MEL-2 and HeLa cells with okadaic acid increased plectin S4642 phosphorylation, suggesting that protein phosphatase 2A dephosphorylates this residue.
Webb11 juli 2016 · RNA-binding proteins (RBPs) have essential roles in determining the fate of RNA from synthesis to decay and have been studied on a protein-by-protein basis, or computationally based on a number of ... WebbObjectives To assess whether BP patients have autoantibodies targeting plectin, another hemidesmosomal component showing extensive homology to BP230. ... Conclusions Our results indicate that sera from BP patients might contain autoantibodies binding to plectin. Although this protein and BP230 are closely sequence-related, ...
Webb20 jan. 2024 · • Characterize Plectin protein that might have a significant role in the intermediate filament assembly and dynamics during an immune response. Show less JSPS Postdoctoral Fellow
Webb21 dec. 2024 · Plectin, as a cytoskeleton-related protein, is involved in various physiological and pathological processes of many cell types. Studies have found that plectin affects cancer cell invasion and metastasis, but the exact mechanism is not fully understood. In this study, we aim to investigate the role of plectin in the migration of … bls oews surveyWebb12 dec. 2005 · To monitor expression of plectin 1 on the protein level and to study its cellular localization, we raised isoform-specific antibodies. Rabbits were immunized with recombinant fusion proteins containing plectin 1-specific sequences, and antibodies highly specific for plectin 1 were obtained by affinity purification. free fullz 2020Webb30 aug. 2024 · Background Melanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the proto-oncogene, Rous sarcoma oncogene (Src), which is highly activated and promotes cell proliferation, migration, adhesion, and metastasis in melanoma. Plectin, a cytoskeletal … bls october reportWebb30 aug. 2024 · Moreover, plectin is a scaffolding protein known to bind to the receptor for activated C kinase 1 (RACK1), thus modulating protein kinase C (PKC) signaling pathways, and it has been shown to interact with phosphatidylinositol-4,5-biphosphate (PIP2) [ 7 ], integrin α6β4 [ 8 ], and calmodulin [ 9 ], among others. bls oews reportWebb8 mars 2024 · cl02102 (PSSM ID: 445667): Conserved Protein Domain Family S10_plectin, This presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein free fully stocked online storePlectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition, plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect … Visa mer Plectin can exist in cells as several alternatively-spliced isoforms, all around 500 kDa and >4000 amino acids. The structure of plectin is thought to be a dimer consisting of a central coiled coil of alpha helices connecting … Visa mer Studies employing a plectin knockout mouse have shed light on the functions of plectin. Pups died 2–3 days after birth, and these mice exhibited marked skin abnormalities, including degeneration of keratinocytes. Skeletal and cardiac muscle tissues were also … Visa mer • Pfendner E, Rouan F, Uitto J (Apr 2005). "Progress in epidermolysis bullosa: the phenotypic spectrum of plectin mutations". Experimental … Visa mer Mutations in PLEC have been associated with epidermolysis bullosa simplex with muscular dystrophy. A missense variant of PLEC has been … Visa mer • List of target antigens in pemphigus Visa mer • Mass spectrometry characterization of one isoform of PLEC at COPaKB. • GeneReviews/NCBI/NIH/UW entry on Epidermolysis Bullosa with Pyloric Atresia • plectin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Visa mer bls office bramptonWebbPlectin is a cytoskeletal linker protein which has a long central rod and N- and C-terminal globular domains. Mutations in the gene encoding plectin (PLEC) cause two distinct … free fullz pastebin